研究業績

大村谷昌樹

原著論文

  1. Taki, K., Ohmuraya, M., Tanji, E., Komatsu, H., Hashimoto, D., Semba, K., Araki, K., Kawaguchi, Y., Baba, H. and Furukawa, T. GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.  Oncogene. in press, 2015.
  2. Nakagawa, Y., Sakuma, T., Sakamoto, T., Ohmuraya, M., Nakagata, N. and Yamamoto, T. Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes.BMC Biotechnol. 15:33. doi: 10.1186/s12896-015-0144-x. 2015.
  3. Ida, S., Ozaki, N., Hirashima, K., Zaitsu, Y., Taki, K., Sakamoto, Y., Miyamoto, Y., Oki, E., Morita, M., Watanabe, M., Maehara, Y., Yamamura, K., Baba, H. and Ohmuraya, M. SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-associated Cancer Mol Cancer Res. in press, 2015.
  4. Hashimoto, D., Chikamoto, A., Sakata, K., Nakagawa, S., Hayashi, H., Ohmuraya, M., Hirota, M., Yoshida, N., Beppu, T. and Baba, H. Staging laparoscopy leads to rapid induction of chemotherapy for unresectable pancreatobiliary cancers. Asian journal of endoscopic surgery. 8:59-62, 2015.
  5. Tsukamoto, M., Hashimoto, D., Chikamoto, A., Abe, S., Ohmuraya, M. and Baba, H. Clinical features and management of pancreatic solid pseudopapillary tumor. Am Surg. 80:1212-1215, 2014.
  6. Sakata, K., Ohmuraya, M., Araki, K., Suzuki, C., Ida, S., Hashimoto, D., Wang, J., Uchiyama, Y., Baba, H. and Yamamura, K. Generation and analysis of serine protease inhibitor Kazal type 3-Cre driver mice. Exp Anim. 63:45-53, 2014.
  7. Ozaki, N., Fukuchi, Y., Tomiyoshi, SR., Uehara, H., Ida, S., Wang, J., Araki, K., Sibilia, M., Baba, H., Yamamura, K. and Ohmuraya, M. Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling. Biochem Biophys Res Commun. 446:224-230, 2014.
  8. Nakagawa, Y., Yamamoto, T., Suzuki, K., Araki, K., Takeda, N., Ohmuraya, M. and Sakuma, T. Screening Methods to Identify TALEN-Mediated Knockout Mice. Exp Anim. 63:79-84, 2014.
  9. Nakagawa, Y., Sakuma, T., Nakagata, N., Yamasaki, S., Takeda, N., Ohmuraya, M. and Yamamoto, T. Application of Oocyte Cryopreservation Technology in TALEN-Mediated Mouse Genome Editing. Exp Anim. 63:349-355, 2014.
  10. Hashimoto, D., Chikamoto, A., Ohmuraya, M., Sakata, K., Miyake, K., Kuroki, H., Watanabe, M., Beppu, T., Hirota, M. and Baba, H. Pancreatic cancer in the remnant pancreas following primary pancreatic resection. Surg Today. 44:1313-1320, 2014.
  11. Hashimoto, D., Chikamoto, A., Ohmuraya, M., Hirota, M. and Baba, H. Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy. Surg Today. 44:1207-1213, 2014.
  12. Hashimoto, D., Chikamoto, A., Ohmuraya, M., Abe, S., Nakagawa, S., Beppu, T., Takamori, H., Hirota, M. and Baba, H. Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer. JPEN J Parenter Enteral Nutr. 2014.
  13. Ozaki, N., Ohmuraya, M., Ida, S., Hashimoto, D., Ikuta, Y., Chikamoto, A., Hirota, M. and Baba, H. Serine protease inhibitor Kazal type 1 and epidermal growth factor receptor are expressed in pancreatic tubular adenocarcinoma, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. J Hepatobiliary Pancreat Sci. 2013.
  14. Hashimoto, D., Chikamoto, A., Ohmuraya, M., Sakata, K., Miyake, K., Kuroki, H., Watanabe, M., Beppu, T., Hirota, M. and Baba, H. Pancreatic cancer in the remnant pancreas following primary pancreatic resection. Surg Today. 2013.
  15. Hashimoto, D., Chikamoto, A., Ohmuraya, M., Hirota, M. and Baba, H. Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy. Surg Today. 2013.
  16. Piao, X., Komazawa-Sakon, S., Nishina, T., Koike, M., Piao, JH., Ehlken, H., Kurihara, H., Hara, M., Van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He, YW. and Nakano, H. c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci Signal. 5:ra93, 2012.
  17. Ohmuraya, M., Sugano, A., Hirota, M., Takaoka, Y. and Yamamura, K. Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis. Front Physiol. 3:126, 2012.
  18. Ohmuraya, M. and Yamamura, K. Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases. Exp Anim. 60:433-444, 2011.
  19. Wang, J., Ohmuraya, M., Suyama, K., Hirota, M., Ozaki, N., Baba, H., Nakagata, N., Araki, K. and Yamamura, K. Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression. Lab Invest. 90:654-664, 2010.
  20. Romac, JM., Ohmuraya, M., Bittner, C., Majeed, MF., Vigna, SR., Que, J., Fee, BE., Wartmann, T., Yamamura, K. and Liddle, RA. Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. Am J Physiol Gastrointest Liver Physiol. 298:G518-524, 2010.
  21. Ida, S., Ohmuraya, M., Hirota, M., Ozaki, N., Hiramatsu, S., Uehara, H., Takamori, H., Araki, K., Baba, H. and Yamamura, K. Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet. Exp Anim. 59:421-429, 2010.
  22. Ozaki, N., Ohmuraya, M., Hirota, M., Ida, S., Wang, J., Takamori, H., Higashiyama, S., Baba, H. and Yamamura, K. Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor. Mol Cancer Res. 7:1572-1581, 2009.
  23. Ida, S., Fujimura, Y., Hirota, M., Imamura, Y., Ozaki, N., Suyama, K., Hashimoto, D., Ohmuraya, M., Tanaka, H., Takamori, H. and Baba, H. Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis. Surg Today. 39:314-319, 2009.
  24. Hashimoto, D., Ohmuraya, M., Wang, J., Yamamura, K., Hirota, M. and Baba, H. Effect of low-molecular weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells. Pancreas. 38:595-597, 2009.
  25. Wang, J., Ohmuraya, M., Hirota, M., Baba, H., Zhao, G., Takeya, M., Araki, K. and Yamamura, K. Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochem Cell Biol. 130:387-397, 2008.
  26. Suyama, K., Ohmuraya, M., Hirota, M., Ozaki, N., Ida, S., Endo, M., Araki, K., Gotoh, T., Baba, H. and Yamamura, K. C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis. Biochem Biophys Res Commun. 367:176-182, 2008.
  27. Ohmuraya, M. and Yamamura, K. Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation. Autophagy. 4:1060-1062, 2008.
  28. Hashimoto, D., Ohmuraya, M., Hirota, M., Yamamoto, A., Suyama, K., Ida, S., Okumura, Y., Takahashi, E., Kido, H., Araki, K., Baba, H., Mizushima, N. and Yamamura, K. Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol. 181:1065-1072, 2008.
  29. Ohmuraya, M., Hirota, M., Araki, K., Baba, H. and Yamamura, K. Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. Pancreas. 33:104-106, 2006.
  30. Maeda, K., Hirota, M., Ichihara, A., Ohmuraya, M., Hashimoto, D., Sugita, H., Takamori, H., Kanemitsu, K. and Baba, H. Applicability of disseminated intravascular coagulation parameters in the assessment of the severity of acute pancreatitis. Pancreas. 32:87-92, 2006.
  31. Ohmuraya, M., Hirota, M., Araki, M., Mizushima, N., Matsui, M., Mizumoto, T., Haruna, K., Kume, S., Takeya, M., Ogawa, M., Araki, K. and Yamamura, K. Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology. 129:696-705, 2005.
  32. Maeda, K., Hirota, M., Kimura, Y., Ichihara, A., Ohmuraya, M., Sugita, H. and Ogawa, M. Proinflammatory role of trypsin and protease-activated receptor-2 in a rat model of acute pancreatitis. Pancreas. 31:54-62, 2005.
  33. Kimura, Y., Hirota, M., Okabe, A., Inoue, K., Kuwata, K., Ohmuraya, M. and Ogawa, M. Dynamic aspects of granulocyte activation in rat severe acute pancreatitis. Pancreas. 27:127-132, 2003.
  34. Inoue, K., Hirota, M., Kimura, Y., Kuwata, K., Ohmuraya, M. and Ogawa, M. Further evidence for endothelin as an important mediator of pancreatic and intestinal ischemia in severe acute pancreatitis. Pancreas. 26:218-223, 2003.
  35. Hirota, M., Kuwata, K., Ohmuraya, M. and Ogawa, M. From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene. JOP. 4:83-88, 2003.
  36. Hirota, M., Inoue, K., Kimura, Y., Mizumoto, T., Kuwata, K., Ohmuraya, M., Ishiko, T., Beppu, T. and Ogawa, M. Non-occlusive mesenteric ischemia and its associated intestinal gangrene in acute pancreatitis. Pancreatology. 3:316-322, 2003.
  37. Ikeda, S., Sera, Y., Yoshida, M., Izaki, T., Uchino, S., Endo, F., Ohmuraya, M. and Beppu, T. Successful coil embolization in an infant with congenital intrahepatic portosystemic shunts. J Pediatr Surg. 34:1031-1032, 1999.
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